Glioblastoma is a highly aggressive brain tumor constituted by glioma stem cell and differentiated cell populations with distinct susceptibility to cytotoxic T lymphocytes crucial for tumor immune surveillance. In this issue of The EMBO Journal, Bassoy et al (2017) show that the surface expression of certain glycans that favor recognition and killing by T cells depends on mitochondrial contacts with the endoplasmic reticulum, extending the function of this interface even to immune recognition.
See also: EY Bassoy et al
The key organelles in energy production, mitochondria, have also been bestowed with other crucial cellular functions, including regulation of apoptosis, metabolism, and calcium homeostasis. Mitochondria are dynamic organelles, which undergo constant fusion and fission. In mammals, mitofusins (1 and 2) and Opa1 are involved in outer and inner mitochondrial membrane fusion, whereas dynamin‐related protein 1 (Drp1) has been extensively studied for its role in mitochondrial fission, along with its receptors on the mitochondrial outer membrane mitochondrial fission factor (Mff), fission 1 (Fis1), and mitochondrial division (MiD) 49 and 51 (Pernas & Scorrano, 2016). The discovery of the molecular mediators of mitochondrial shape changes allowed the identification of the role of mitochondrial morphology in various complex cellular processes, ranging from apoptosis to metabolism to cancer susceptibility and even to differentiation (Pernas & Scorrano, 2016). Mitochondrial shape is crucial in determining identity, maintenance, and renewal of stem cells (Xie et al, 2015). While these aspects might be attributed to …
Subscribers, please sign in with your username and password.